Affordable Access

deepdyve-link
Publisher Website

The type 2 diabetes gene product STARD10 is a phosphoinositide-binding protein that controls insulin secretory granule biogenesis

Authors
  • Carrat, Gaelle R.1
  • Haythorne, Elizabeth1
  • Tomas, Alejandra1
  • Haataja, Leena2
  • Müller, Andreas3, 4, 5, 6
  • Arvan, Peter2
  • Piunti, Alexandra1,
  • Cheng, Kaiying7
  • Huang, Mutian1
  • Pullen, Timothy J.1, 8
  • Georgiadou, Eleni1
  • Stylianides, Theodoros9
  • Amirruddin, Nur Shabrina10, 11
  • Salem, Victoria1, 12
  • Distaso, Walter13
  • Cakebread, Andrew14
  • Heesom, Kate J.15
  • Lewis, Philip A.15
  • Hodson, David J.16, 17, 18
  • Briant, Linford J.19
  • And 11 more
  • 1 Section of Cell Biology and Functional Genomics, Imperial College London, du Cane Road, London, W12 0NN, UK
  • 2 Division of Metabolism, Endocrinology & Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA
  • 3 Molecular Diabetology, University Hospital and Faculty of Medicine Carl Gustav Carus, TU Dresden, Dresden, Germany
  • 4 Paul Langerhans Institute Dresden (PLID) of the Helmholtz Center Munich, University Hospital Carl Gustav Carus and Faculty of Medicine of the TU Dresden, Dresden, Germany
  • 5 German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany
  • 6 Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG), Dresden, Germany
  • 7 Section of Structural Biology, Department of Medicine, Imperial College London, London, UK
  • 8 Department of Diabetes, Faculty of Life Science and Medicine, King's College London, London, UK
  • 9 Loughborough University, Centre of Innovative and Collaborative Construction Engineering, Leicestershire, LE11 3TU, UK
  • 10 Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology (IMCB), A∗STAR, Proteos, Singapore, 138673, Singapore
  • 11 Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore
  • 12 Section of Investigative Medicine, Department of Medicine, Imperial College London, du Cane Road, London, W12 0NN, UK
  • 13 Imperial College Business School, Imperial College London, Exhibition Road, London, SW7 2AZ, UK
  • 14 London Metallomics Facility, King's College London, Strand, London, WC2R 2LS, UK
  • 15 Proteomics Facility, University of Bristol, Bristol, UK
  • 16 Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK
  • 17 Institute of Metabolism and Systems Research, University of Birmingham, Edgbaston, UK
  • 18 Centre of Membrane Proteins and Receptors, University of Birmingham and University of Nottingham, Midlands, UK
  • 19 Oxford Centre for Diabetes, Endocrinology, and Metabolism, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, OX3 7LE, UK
  • 20 Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong
  • 21 School of Biochemistry, Faculty of Life Sciences, University of Bristol, Bristol, BS8 1TD, UK
  • 22 Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Institut National de la Santé et de la Recherche Médicale (INSERM) U1258, Centre National de la Recherche Scientifique (CNRS), UMR 7104, Université de Strasbourg, 1 rue Laurent Fries, 67404 Illkirch, France
  • 23 Singapore Lipidomics Incubator, Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Mdical Drive, Singapore, 117596, Singapore
  • 24 Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117596, Singapore
Type
Published Article
Journal
Molecular Metabolism
Publisher
Elsevier BV
Publication Date
May 13, 2020
Volume
40
Identifiers
DOI: 10.1016/j.molmet.2020.101015
PMID: 32416313
PMCID: PMC7322359
Source
PubMed Central
Keywords
License
Unknown

Abstract

• β Stard10 KO β-cells show altered granule morphology. • Deletion of Stard10 increased basal secretion of newly synthesised proinsulin. • β Stard10 KO islets had an altered lipidomics profile, including phosphatidylinositols. • STARD10 bound to phosphoinositides in a lipid overlay assay. • STARD10 structure reveals that its cavity readily accommodates phosphatidylinositols.

Report this publication

Statistics

Seen <100 times