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Two-year clinical evaluation of a proanthocyanidins-based primer in non-carious cervical lesions: a double-blind randomized clinical trial.

Authors
  • de Souza, Lidiane Costa1
  • Sousa Rodrigues, Nara2
  • Araújo Cunha, Diana3
  • Pinheiro Feitosa, Victor4
  • Lima Santiago, Sérgio5
  • Reis, Alessandra6
  • Dourado Loguercio, Alessandro7
  • Perdigão, Jorge8
  • de Paulo Aragão Saboia, Vicente9
  • 1 Postgraduate Program of Dentistry - Faculty of Pharmacy, Dentistry and Nursing, Federal University of Ceará, Fortaleza, Ceará, Brazil. Electronic address: [email protected] , (Brazil)
  • 2 Postgraduate Program of Dentistry - Faculty of Pharmacy, Dentistry and Nursing, Federal University of Ceará, Fortaleza, Ceará, Brazil. Electronic address: [email protected] , (Brazil)
  • 3 Postgraduate Program of Dentistry - Faculty of Pharmacy, Dentistry and Nursing, Federal University of Ceará, Fortaleza, Ceará, Brazil. Electronic address: [email protected] , (Brazil)
  • 4 Postgraduate Program of Dentistry - Faculty of Pharmacy, Dentistry and Nursing, Federal University of Ceará, Fortaleza, Ceará, Brazil; Paulo Picanço School of Dentistry, Fortaleza, Brazil. Electronic address: [email protected] , (Brazil)
  • 5 Postgraduate Program of Dentistry - Faculty of Pharmacy, Dentistry and Nursing, Federal University of Ceará, Fortaleza, Ceará, Brazil. Electronic address: [email protected] , (Brazil)
  • 6 School of Dentistry, Department of Restorative Dentistry, State University of Ponta Grossa, Ponta Grossa, Parana, Brazil. Electronic address: [email protected] , (Brazil)
  • 7 School of Dentistry, Department of Restorative Dentistry, State University of Ponta Grossa, Ponta Grossa, Parana, Brazil. Electronic address: [email protected] , (Brazil)
  • 8 Department of Restorative Sciences, University of Minnesota, Minneapolis, MN, USA. Electronic address: [email protected]
  • 9 Postgraduate Program of Dentistry - Faculty of Pharmacy, Dentistry and Nursing, Federal University of Ceará, Fortaleza, Ceará, Brazil. Electronic address: [email protected] , (Brazil)
Type
Published Article
Journal
Journal of dentistry
Publication Date
Mar 20, 2020
Pages
103325–103325
Identifiers
DOI: 10.1016/j.jdent.2020.103325
PMID: 32205201
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

This double-blind randomized clinical trial evaluated the influence of pre-treatment with proanthocyanidins (PA) from grape seed extract on the clinical behavior of a simplified etch-and-rinse adhesive placed in non-carious cervical lesions (NCCLs) over 6- and 24-months. A total of 135 restorations were randomly inserted in 45 subjects. The NCCLs were etched with 37% phosphoric acid for 15 s and distributed into 3 groups: Control (PA0) - adhesive ExciTE F applied as per the manufacturer's recommendations; PA2 and PA5 groups - 2 wt% and 5 wt% PA solution, respectively, were applied for 60 s and washed for 30 s prior to application of the adhesive. The resin composite was placed incrementally and light-cured. The restorations were evaluated at baseline, 6 months (6 m) and 24 months (24 m) using both the FDI and USPHS criteria. Statistical analyses were carried out using Friedman repeated-measures analysis of variance by rank and the Wilcoxon test (α = 0.05). The retention rates were 98% (PA0), 98% (PA2) and 83% (PA5) after 6 m and 93% (PA0), 89% (PA2) and 70% (PA5) after 24 m. Only PA5 resulted in a significant lower retention rate at 6 m and at 24 m compared with that of baseline (p = 0.03). All groups resulted in a significantly worse marginal adaptation and marginal staining for the FDI criteria when the baseline vs. the 24 m recall data were compared. These differences were considered clinically acceptable under the FDI criteria. The application of PA as a primer did not result in clinical advantages after 24 m of clinical service, regardless of the concentration used. It has been reported that PA, a collagen crosslinking agent, increases the durability of the dentin-resin interface. However, no effects were found clinically after 24 months. Copyright © 2020. Published by Elsevier Ltd.

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