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Two-hit wonders: The expanding universe of multitargeting epigenetic agents.

Authors
  • de Lera, Angel R1
  • Ganesan, A2
  • 1 Departamento de Química Orgánica, Facultade de Química, CINBIO and IIS Galicia Sur, Universidade de Vigo, 36310 Vigo, Spain. Electronic address: [email protected] , (Spain)
  • 2 School of Pharmacy, University of East Anglia, Norwich NR4 7TJ, United Kingdom. Electronic address: [email protected] , (United Kingdom)
Type
Published Article
Journal
Current opinion in chemical biology
Publication Date
Aug 09, 2020
Volume
57
Pages
135–154
Identifiers
DOI: 10.1016/j.cbpa.2020.05.009
PMID: 32784072
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Multitargeting involves the application of molecules that are deliberately intended to bind to two or more unrelated cellular targets with high affinity. In epigenetic chemical biology and drug discovery, the rational design of multitargeting agents has evolved to a sophisticated level, and there are now five examples that have reached clinical trials. This review covers recent developments in the field and future prospects. Copyright © 2020 Elsevier Ltd. All rights reserved.

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