Two-hit wonders: The expanding universe of multitargeting epigenetic agents.
Departamento de Química Orgánica, Facultade de Química, CINBIO and IIS Galicia Sur, Universidade de Vigo, 36310 Vigo, Spain. Electronic address: [email protected]
School of Pharmacy, University of East Anglia, Norwich NR4 7TJ, United Kingdom. Electronic address: [email protected]
- Published Article
Current opinion in chemical biology
- Publication Date
Aug 09, 2020
Multitargeting involves the application of molecules that are deliberately intended to bind to two or more unrelated cellular targets with high affinity. In epigenetic chemical biology and drug discovery, the rational design of multitargeting agents has evolved to a sophisticated level, and there are now five examples that have reached clinical trials. This review covers recent developments in the field and future prospects. Copyright © 2020 Elsevier Ltd. All rights reserved.
Report this publication
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
This record was last updated on 09/02/2020 and may not reflect the most current and accurate biomedical/scientific data available from NLM.
The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/32784072