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Two triterpeniods from Cyclocarya paliurus (Batal) Iljinsk (Juglandaceae) promote glucose uptake in 3T3-L1 adipocytes: The relationship to AMPK activation.

Authors
  • Zhu, K N1
  • Jiang, C H2
  • Tian, Y S3
  • Xiao, N3
  • Wu, Z F4
  • Ma, Y L4
  • Lin, Z4
  • Fang, S Z5
  • Shang, X L5
  • Liu, K3
  • Zhang, J2
  • Liu, B L6
  • Yin, Z Q7
  • 1 Department of Natural Medicinal Chemistry & State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, Jiangsu Province, PR China; Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing 211198, Jiangsu Province, PR China. , (China)
  • 2 Laboratory of Translational Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing 210028, Jiangsu Province, PR China. , (China)
  • 3 Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing 211198, Jiangsu Province, PR China. , (China)
  • 4 Department of Natural Medicinal Chemistry & State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, Jiangsu Province, PR China; Laboratory of Translational Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing 210028, Jiangsu Province, PR China. , (China)
  • 5 College of Forest Resources and Environment, Nanjing Forestry University, Nanjing 210042, Jiangsu Province, PR China. , (China)
  • 6 Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing 211198, Jiangsu Province, PR China. Electronic address: [email protected] , (China)
  • 7 Department of Natural Medicinal Chemistry & State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, Jiangsu Province, PR China. Electronic address: [email protected] , (China)
Type
Published Article
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
Publication Date
Aug 15, 2015
Volume
22
Issue
9
Pages
837–846
Identifiers
DOI: 10.1016/j.phymed.2015.05.058
PMID: 26220631
Source
Medline
Keywords
License
Unknown

Abstract

CPEC and its two triterpenoids promoted glucose uptake in the absence of insulin, as well as ameliorated IRS-1/PI3K/Akt pathway by inhibiting inflammation. These effects were related to the regulation of AMPK activity.

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