Two regions of the bifunctional protein aspartokinase I- homoserine dehydrogenase I are connected by a short hinge.
- Published Article
The Journal of biological chemistry
- Publication Date
Oct 25, 1981
Four proteases differing in their specificity, i.e. subtilisin, trypsin, alpha-chymotrypsin and V8 staphylococcal protease, cleave the bifunctional protein Escherichia coli aspartokinase I-homoserine dehydrogenase I (composed of 820 residues) producing an active homoserine dehydrogenase fragment. This cleavage occurs within a short segment of the polypeptide chain extending from residue 293 to residue 300.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/7026556