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Two distinct broadly neutralizing antibody specificities of different clonal lineages in a single HIV-1-infected donor: implications for vaccine design.

Authors
  • Bonsignori, Mattia
  • Montefiori, David C
  • Wu, Xueling
  • Chen, Xi
  • Hwang, Kwan-Ki
  • Tsao, Chun-Yen
  • Kozink, Daniel M
  • Parks, Robert J
  • Tomaras, Georgia D
  • Crump, John A
  • Kapiga, Saidi H
  • Sam, Noel E
  • Kwong, Peter D
  • Kepler, Thomas B
  • Liao, Hua-Xin
  • Mascola, John R
  • Haynes, Barton F
Type
Published Article
Journal
Journal of Virology
Publisher
American Society for Microbiology
Publication Date
Apr 01, 2012
Volume
86
Issue
8
Pages
4688–4692
Identifiers
DOI: 10.1128/JVI.07163-11
PMID: 22301150
Source
Medline
License
Unknown

Abstract

Plasma from a small subset of subjects chronically infected with HIV-1 shows remarkable magnitude and breadth of neutralizing activity. From one of these individuals (CH0219), we isolated two broadly neutralizing antibodies (bnAbs), CH01 and VRC-CH31, from two clonal lineages of memory B cells with distinct specificities (variable loop 1 and 2 [V1V2] conformational specificity and CD4-binding site specificity, respectively) that recapitulate 95% of CH0219 serum neutralization breadth. These data provide proof of concept for an HIV-1 vaccine that aims to elicit bnAbs of multiple specificities.

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