Affordable Access

Publisher Website

Two computational regimes of a single-compartment neuron separated by a planar boundary in conductance space.

Authors
Type
Published Article
Journal
Neural Computation
0899-7667
Publisher
MIT Press
Publication Date
Volume
20
Issue
5
Pages
1239–1260
Identifiers
DOI: 10.1162/neco.2007.05-07-536
PMID: 18194104
Source
Medline

Abstract

Recent in vitro data show that neurons respond to input variance with varying sensitivities. Here we demonstrate that Hodgkin-Huxley (HH) neurons can operate in two computational regimes: one that is more sensitive to input variance (differentiating) and one that is less sensitive (integrating). A boundary plane in the 3D conductance space separates these two regimes. For a reduced HH model, this plane can be derived analytically from the V nullcline, thus suggesting a means of relating biophysical parameters to neural computation by analyzing the neuron's dynamical system.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments
F