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Two-component approach toward a fully substituted N-fused pyrrole ring.

Authors
  • Chernyak, Dmitri
  • Skontos, Cathy
  • Gevorgyan, Vladimir
Type
Published Article
Journal
Organic Letters
Publisher
American Chemical Society
Publication Date
Jul 16, 2010
Volume
12
Issue
14
Pages
3242–3245
Identifiers
DOI: 10.1021/ol1011949
PMID: 20545315
Source
Medline
License
Unknown

Abstract

An efficient two-component palladium-catalyzed arylation/cyclization cascade approach toward a variety of N-fused pyrroloheterocycles has been developed. This transformation proceeds via the palladium-catalyzed coupling of aryl halides with propargylic esters or ethers followed by the 5-endo-dig cyclization leading to highly functionalized pyrroloheterocycles in good to excellent yield.

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