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Twinrix vaccination schedules among injecting drug users.

Authors
  • Brim, Nancy
  • Zaller, Nickolas
  • Taylor, Lynn E
  • Feller, Ed
Type
Published Article
Journal
Expert Opinion on Biological Therapy
Publisher
Informa UK (Ashley Publications)
Publication Date
Mar 01, 2007
Volume
7
Issue
3
Pages
379–389
Identifiers
PMID: 17309329
Source
Medline
License
Unknown

Abstract

Twinrix is the only licensed vaccine that provides dual protection against infection with hepatitis A virus (HAV) and hepatitis B virus (HBV). The standard vaccination schedule for Twinrix is 0, 1 and 6 months. However, many high-risk populations, such as injecting drug users (IDUs), do not complete the vaccination series and, thus, do not acquire sufficient immunity against HAV and HBV. Twinrix can be administered using an accelerated vaccination schedule of 0, 7 and 21 days, with a booster recommended at 12 months. This manuscript reviews the available literature on vaccinating IDUs against HAV and HBV. The authors conclude that there is insufficient evidence regarding whether the accelerated Twinrix HAV/HBV vaccination schedule would yield a greater number of IDUs protected against both HAV and HBV.

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