The TUTase URT1 connects decapping activators and prevents the accumulation of excessively deadenylated mRNAs to avoid siRNA biogenesis
- Authors
- Type
- Published Article
- Journal
- Nature Communications
- Publisher
- Springer Nature
- Publication Date
- Feb 26, 2021
- Volume
- 12
- Issue
- 1
- Identifiers
- DOI: 10.1038/s41467-021-21382-2
- Source
- Springer Nature
- License
- Green
Abstract
TUTase mediated uridylation of mRNA promotes degradation. Here, Scheer, de Almeida et al. show that Arabidopsis TUTase URT1 interacts directly with the translation inhibitor and decay factor DECAPPING5 and suppresses siRNA biogenesis by preventing accumulation of deadenylated mRNAs