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The TUTase URT1 connects decapping activators and prevents the accumulation of excessively deadenylated mRNAs to avoid siRNA biogenesis

Authors
  • Scheer, Hélène1
  • de Almeida, Caroline1
  • Ferrier, Emilie1
  • Simonnot, Quentin1
  • Poirier, Laure1
  • Pflieger, David1
  • Sement, François M.1
  • Koechler, Sandrine1
  • Piermaria, Christina2
  • Krawczyk, Paweł3, 4
  • Mroczek, Seweryn3, 4
  • Chicher, Johana2
  • Kuhn, Lauriane2
  • Dziembowski, Andrzej3, 4
  • Hammann, Philippe2
  • Zuber, Hélène1
  • Gagliardi, Dominique1
  • 1 Institut de biologie moléculaire des plantes, CNRS, Université de Strasbourg, Strasbourg, France , Strasbourg (France)
  • 2 Plateforme Protéomique Strasbourg Esplanade du CNRS, Université de Strasbourg, Strasbourg, France , Strasbourg (France)
  • 3 International Institute of Molecular and Cell Biology, Warsaw, Poland , Warsaw (Poland)
  • 4 Institute of Genetics and Biotechnology, University of Warsaw, Warsaw, Poland , Warsaw (Poland)
Type
Published Article
Journal
Nature Communications
Publisher
Springer Nature
Publication Date
Feb 26, 2021
Volume
12
Issue
1
Identifiers
DOI: 10.1038/s41467-021-21382-2
Source
Springer Nature
License
Green

Abstract

TUTase mediated uridylation of mRNA promotes degradation. Here, Scheer, de Almeida et al. show that Arabidopsis TUTase URT1 interacts directly with the translation inhibitor and decay factor DECAPPING5 and suppresses siRNA biogenesis by preventing accumulation of deadenylated mRNAs

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