The TUTase URT1 connects decapping activators and prevents the accumulation of excessively deadenylated mRNAs to avoid siRNA biogenesis

Hélène Scheer; Caroline de Almeida; Emilie Ferrier; Quentin Simonnot; Laure Poirier; David Pflieger; François M. Sement; Sandrine Koechler; Christina Piermaria; Paweł Krawczyk; Seweryn Mroczek; Johana Chicher; Lauriane Kuhn; Andrzej Dziembowski; Philippe Hammann; Hélène Zuber; Dominique Gagliardi

doi:10.1038/s41467-021-21382-2

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The TUTase URT1 connects decapping activators and prevents the accumulation of excessively deadenylated mRNAs to avoid siRNA biogenesis

Authors

Scheer, Hélène¹
de Almeida, Caroline¹
Ferrier, Emilie¹
Simonnot, Quentin¹
Poirier, Laure¹
Pflieger, David¹
Sement, François M.¹
Koechler, Sandrine¹
Piermaria, Christina²
Krawczyk, Paweł^{3, 4}
Mroczek, Seweryn^{3, 4}
Chicher, Johana²
Kuhn, Lauriane²
Dziembowski, Andrzej^{3, 4}
Hammann, Philippe²
Zuber, Hélène¹
Gagliardi, Dominique¹

¹ Institut de biologie moléculaire des plantes, CNRS, Université de Strasbourg, Strasbourg, France , Strasbourg (France)
² Plateforme Protéomique Strasbourg Esplanade du CNRS, Université de Strasbourg, Strasbourg, France , Strasbourg (France)
³ International Institute of Molecular and Cell Biology, Warsaw, Poland , Warsaw (Poland)
⁴ Institute of Genetics and Biotechnology, University of Warsaw, Warsaw, Poland , Warsaw (Poland)

Type

Published Article

Journal

Nature Communications

Publisher

Springer Nature

Publication Date

Feb 26, 2021

Volume

12

Issue

1

Identifiers

DOI: 10.1038/s41467-021-21382-2

Source

Springer Nature

License

Green

Abstract

TUTase mediated uridylation of mRNA promotes degradation. Here, Scheer, de Almeida et al. show that Arabidopsis TUTase URT1 interacts directly with the translation inhibitor and decay factor DECAPPING5 and suppresses siRNA biogenesis by preventing accumulation of deadenylated mRNAs

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