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Turning the tide: targeting PfCRT to combat drug-resistant P. falciparum?

Authors
  • Small-Saunders, Jennifer L.1
  • Hagenah, Laura M.1
  • Fidock, David A.1, 1
  • 1 Columbia University Irving Medical Center, New York, NY, USA , New York (United States)
Type
Published Article
Journal
Nature Reviews Microbiology
Publisher
Springer Nature
Publication Date
Apr 16, 2020
Volume
18
Issue
5
Pages
261–262
Identifiers
DOI: 10.1038/s41579-020-0353-8
Source
Springer Nature
License
Yellow

Abstract

Resistance to the current first-line antimalarials threatens the control of malaria caused by Plasmodium falciparum and underscores the urgent need for new drugs with novel modes of action. Small-Saunders, Hagenah and Fidock present the argument that the parasite’s chloroquine resistance transporter (PfCRT) constitutes a promising target to combat multidrug-resistant malaria.

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