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Tumour associated vasculature-on-a-chip for the evaluation of microbubble-mediated delivery of targeted liposomes †

Authors
  • Bourn, Matthew D.
  • Mohajerani, Safoura Zahed
  • Mavria, Georgia
  • Ingram, Nicola
  • Coletta, P. Louise
  • Evans, Stephen D.
  • Peyman, Sally A.
Type
Published Article
Journal
Lab on a Chip
Publisher
The Royal Society of Chemistry
Publication Date
Feb 06, 2023
Volume
23
Issue
6
Pages
1674–1693
Identifiers
DOI: 10.1039/d2lc00963c
PMID: 36779251
PMCID: PMC10013341
Source
PubMed Central
Disciplines
  • Chemistry
License
Unknown

Abstract

Increased accumulation of targeted liposomes was observed in cultures mimicking tumour-associated vasculature, when compared to healthy vasculature cultures. Microbubble-mediated liposome delivery was found to further increase liposome accumulation.

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