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Tumors sound the alarmin(s).

Authors
  • Coffelt, Seth B
  • Scandurro, Aline B
Type
Published Article
Journal
Cancer Research
Publisher
American Association for Cancer Research
Publication Date
Aug 15, 2008
Volume
68
Issue
16
Pages
6482–6485
Identifiers
DOI: 10.1158/0008-5472.CAN-08-0044
PMID: 18701469
Source
Medline
License
Unknown

Abstract

Recent evidence suggests that inflammatory molecules play critical roles in the development and progression of numerous tumors. However, one specific group of inflammatory molecules whose importance has been established in host immune responses, termed alarmins, has been largely overlooked in cancer biology. The function of several alarmins-including the defensins, LL-37, and HMGB1-in tumor development, progression, or suppression is discussed here. Taken together, these studies indicate that alarmins represent potential new targets for manipulation in a variety of tumors.

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