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Tumor-infiltrating platelets predict postoperative recurrence and survival in resectable pancreatic neuroendocrine tumor.

Authors
  • Xu, Shuai-Shuai1
  • Xu, Hua-Xiang1
  • Wang, Wen-Quan1
  • Li, Shuo1
  • Li, Hao1
  • Li, Tian-Jiao1
  • Zhang, Wu-Hu1
  • Liu, Liang2
  • Yu, Xian-Jun1
  • 1 Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 20032, China. , (China)
  • 2 Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 20032, China. [email protected] , (China)
Type
Published Article
Journal
World journal of gastroenterology
Publication Date
Nov 07, 2019
Volume
25
Issue
41
Pages
6248–6257
Identifiers
DOI: 10.3748/wjg.v25.i41.6248
PMID: 31749595
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Platelets have been reported to participate in tumor cell growth, extravasation, epithelial-mesenchymal transition, metastasis, and drug resistance. However, the importance of platelets in pancreatic neuroendocrine tumor (pNET) lacks adequate literature support. The predictive value of tumor-infiltrating platelets (TIPs) in pNET remains unclear. To investigate the relationship between TIPs and the prognosis of patients with pNET following radical resection. In total, 113 patients who had undergone radical surgical resection with a pathologic diagnosis of pNET were enrolled in this study. Immunohistochemical analysis of cluster of differentiation 42b (CD42b) expression in the tumor specimens was performed to determine the presence of TIPs. Univariate and multivariate analyses were used to analyze the prognostic value of TIPs. TIPs were observed in intratumoral areas in 54 patients. Neither basic characteristics nor preoperative platelet-associated indicators showed a significant relationship with the presence of TIPs (all P > 0.05). Patients with positive intratumoral CD42b expression had worse overall survival (P = 0.005) and recurrence-free survival (P < 0.001) than those with negative intratumoral CD42b expression. Multivariate analysis demonstrated that TIPs were independent prognostic factors for overall survival (P = 0.049) and recurrence-free survival (P = 0.003). Nevertheless, platelet count, mean platelet volume, and platelet-to-lymphocyte ratio were not associated with postoperative survival or recurrence in pNET patients (all P > 0.05). TIPs are a useful prognostic biomarker for patients with resectable pNET, and their detection represents a promising tool for pNET treatment strategy decisions. ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.

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