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Tumor-associated immune cell infiltrate density in penile squamous cell carcinomas.

Authors
  • Hladek, Luca1
  • Bankov, Katrin1
  • von der Grün, Jens2
  • Filmann, Natalie3
  • Demes, Melanie1
  • Vallo, Stefan4, 5
  • Wild, Peter J1, 6, 7
  • Winkelmann, Ria8
  • 1 Dr. Senckenberg Institute of Pathology, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany. , (Germany)
  • 2 Department of Radiotherapy and Oncology, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany. , (Germany)
  • 3 Institute of Biostatistics and Mathematical Modeling, Goethe University, Frankfurt am Main, Germany. , (Germany)
  • 4 Institute of Medical Virology, Goethe University Frankfurt, Frankfurt am Main, Germany. , (Germany)
  • 5 Urologie an der Zeil, Frankfurt am Main, Germany. , (Germany)
  • 6 Frankfurt Institute for Advanced Studies (FIAS), Frankfurt am Main, Germany. , (Germany)
  • 7 Wildlab, University Hospital Frankfurt MVZ GmbH, Frankfurt am Main, Germany. , (Germany)
  • 8 Dr. Senckenberg Institute of Pathology, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany. [email protected] , (Germany)
Type
Published Article
Journal
Virchows Archiv
Publisher
Springer Berlin Heidelberg
Publication Date
Jun 01, 2022
Volume
480
Issue
6
Pages
1159–1169
Identifiers
DOI: 10.1007/s00428-022-03271-1
PMID: 35024940
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Penile squamous cell carcinomas are rare tumor entities throughout Europe. Early lymphonodal spread urges for aggressive therapeutic approaches in advanced tumor stages. Therefore, understanding tumor biology and its microenvironment and correlation with known survival data is of substantial interest in order to establish treatment strategies adapted to the individual patient. Fifty-five therapy naïve squamous cell carcinomas, age range between 41 and 85 years with known clinicopathological data, were investigated with the use of tissue microarrays (TMA) regarding the tumor-associated immune cell infiltrate density (ICID). Slides were stained with antibodies against CD3, CD8 and CD20. An image analysis software was applied for evaluation. Data were correlated with clinicopathological characteristics and overall survival. There was a significant increase of ICID in squamous cell carcinomas of the penis in relation to tumor adjacent physiological tissue. Higher CD3-positive ICID was significantly associated with lower tumor stage in our cohort. The ICID was not associated with overall survival. Our data sharpens the view on tumor-associated immune cell infiltrate in penile squamous cell carcinomas with an unbiased digital and automated cell count. Further investigations on the immune cell infiltrate and its prognostic and possible therapeutic impact are needed. © 2022. The Author(s).

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