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Tumoral stem cell reprogramming as a driver of cancer: Theory, biological models, implications in cancer therapy

Authors
  • Vicente-Dueñas, Carolina
  • Hauer, Julia
  • Ruiz-Roca, Lucía
  • Ingenhag, Deborah
  • Rodríguez-Meira, Alba
  • Auer, Franziska
  • Borkhardt, Arndt
  • Sánchez-García, Isidro1, 2, 3
  • 1 Experimental Therapeutics and Translational Oncology Program, Instituto de Biología Molecular y Celular del Cáncer, CSIC/Universidad de Salamanca
  • 2 Institute of Biomedical Research of Salamanca (IBSAL)
  • 3 Department of Pediatric Oncology, Hematology and Clinical Immunology, University Children's Hospital, Medical Faculty, Heinrich Heine University
Type
Published Article
Journal
Seminars in Cancer Biology
Publication Date
Jan 01, 2014
Identifiers
DOI: 10.1016/j.semcancer.2014.02.001
Source
Elsevier
Keywords
License
Unknown

Abstract

Cancer is a clonal malignant disease originated in a single cell and characterized by the accumulation of partially differentiated cells that are phenotypically reminiscent of normal stages of differentiation. According to current models, therapeutic strategies that block oncogene activity are likely to selectively target tumor cells. However, recent evidences have revealed that cancer stem cells could arise through a tumor stem cell reprogramming mechanism, suggesting that genetic lesions that initiate the cancer process might be dispensable for tumor progression and maintenance. This review addresses the impact of these results toward a better understanding of cancer development and proposes new approaches to treat cancer in the future.

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