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Tumor-specific immunotherapy of murine bladder cancer with butanol-extracted antigens and ethylchlorformate polymerized tumor protein.

Authors
  • Rochester, M G
  • Sarosdy, M F
  • Pickett, S H
  • Stogdill, B J
  • Lamm, D L
Type
Published Article
Journal
The Journal of Urology
Publisher
Elsevier
Publication Date
Sep 01, 1988
Volume
140
Issue
3
Pages
647–650
Identifiers
PMID: 3411695
Source
Medline
License
Unknown

Abstract

Successful treatment of superficial bladder cancer using nonspecific immunotherapy with Bacillus Calmette-Guerin (BCG) has been well documented. Investigation of two potential tumor-specific immunotherapeutic agents using a murine transitional-cell carcinoma model (MBT-2) is reported. The survival of mice immunized with tumor proteins obtained by treating tumor cells with either 1-butanol or ethylchlorformate was compared to the survival of animals immunized with BCG. Long-term immunity conferred by each of these agents was also assessed. Significant protection by both agents was noted in all treatment groups compared to controls. Long-term immunity was also found to result from treatment with both investigational agents as well as with BCG. Butanol-extracted antigens and ethylchlorformate polymerized tumor protein may be useful as immunotherapeutic alternatives to BCG.

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