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Tumor necrosis factor-α induces expression and release of interleukin-6 by human urothelial cells.

Authors
  • Wang, Zun-Yi
  • Bjorling, Dale E
Type
Published Article
Journal
Inflammation research : official journal of the European Histamine Research Society ... [et al.]
Publication Date
Jun 01, 2011
Volume
60
Issue
6
Pages
525–532
Identifiers
DOI: 10.1007/s00011-010-0298-x
PMID: 21191629
Source
Medline
License
Unknown

Abstract

These results demonstrate that TNF-α increases expression and release of IL-6 by HUCs and that the effects of TNF-α are mediated by TNFR1. Also, the ERK1/2 and JNK pathways are involved in TNF-α-induced expression and release of IL-6 in HUCs and may represent therapeutic targets in inflammatory urinary tract diseases.

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