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Tumor necrosis factor-α antagonist reduces apoptosis of neurons and oligodendroglia in rat spinal cord injury.

Authors
  • Chen, Ke-Bing
  • Uchida, Kenzo
  • Nakajima, Hideaki
  • Yayama, Takafumi
  • Hirai, Takayuki
  • Watanabe, Shuji
  • Guerrero, Alexander Rodriguez
  • Kobayashi, Shigeru
  • Ma, Wei-Ying
  • Liu, Shao-Yu
  • Baba, Hisatoshi
Type
Published Article
Journal
Spine
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Aug 01, 2011
Volume
36
Issue
17
Pages
1350–1358
Identifiers
DOI: 10.1097/BRS.0b013e3181f014ec
PMID: 21224756
Source
Medline
License
Unknown

Abstract

Our results indicated that etanercept reduces the associated tissue damage of spinal cord injury, improves hindlimb locomotor function, and facilitates myelin regeneration. This positive effect of etanercept on spinal cord injury is probably attributable to the suppression of TNF-α, TNFR1, TNFR2, and activated caspase-3 and caspase-8 overexpressions, and the inhibition of neuronal and oligodendroglial apoptosis.

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