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Tumor induction in developing frog kidneys by a zonal centrifuge purified fraction of the frog herpes-type virus.

Authors
  • Mizell, M
  • Toplin, I
  • Isaacs, J J
Type
Published Article
Journal
Science (New York, N.Y.)
Publication Date
Sep 12, 1969
Volume
165
Issue
3898
Pages
1134–1137
Identifiers
PMID: 5801595
Source
Medline
License
Unknown

Abstract

Injection of frog embryos (Rana pipiens) with a zonal centrifuge purified fraction of herpes-type virus (prepared from virus-containing Lucké tumors) resulted in a high incidence of kidney tumors. This partially purified oncogenic fraction contained a high concentration of an enveloped form of the frog herpes-type virus (adjacent fractions lacked this particle and were not oncogenic), which suggests that this form of the virus plays a role in the genesis of the Lucké tumor.

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