Affordable Access

Tumor detection with carbon-11-labelled amino acids.

Authors
  • Kubota, K
  • Yamada, K
  • Fukada, H
  • Endo, S
  • Ito, M
  • Abe, Y
  • Yamaguchi, T
  • Fujiwara, T
  • Sato, T
  • Ito, K
Type
Published Article
Journal
European journal of nuclear medicine
Publication Date
Jan 01, 1984
Volume
9
Issue
3
Pages
136–140
Identifiers
PMID: 6609075
Source
Medline
License
Unknown

Abstract

A comparative study of tumor detection with ten 11C-labeled amino acids including four newly synthesized amino acids was carried out to find the most valuable 11C-labeled amino acid for the diagnosis of cancer. 11C-L-methionine showed the highest uptake by the experimental rat hepatoma AH109A (2.7% administered dose/g at 20 min, tumor to blood ratio; 11.4). The second highest uptake was of 11C-aminocyclopentane-carboxylic acid (ACPC). The newly synthesized 11C-DL-methyl-ACPC characteristically showed higher accumulation in tumor than in liver and the tumor to liver ratio reached 3.0 at 60 min after injection. It is suggested that 11C-L-methionine and 11C-DL-methyl-ACPC are useful amino acids for the diagnosis of cancer using positron emission tomography.

Report this publication

Statistics

Seen <100 times