Tubulin Role in Cancer Development and Treatment

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Tubulin Role in Cancer Development and Treatment

Authors
  • Dolhyi V1
  • Avierin D1
  • Hojouj M1
  • Bondarenko I1
Type
Published Article
Journal
Asploro Journal of Biomedical and Clinical Case Reports
Publisher
Asploro Open Access Publications
Publication Date
Sep 27, 2019
Volume
2
Issue
2
Pages
15–22
Identifiers
DOI: https://doi.org/10.36502/2019/ASJBCCR.6154
Source
MyScienceWork
Keywords
License
Green

Abstract

This review work is done to show a significance of tubulin in cancer development. Within last decades there are a lot of studies have performed in this area. Now it is clear that there are an enormous number of functions in cell performing by microtubules, a structure unit of which is tubulin. Now it used widely as a predictive factor of tumor aggressiveness, but increasingly it becomes a target for studying and treatment elaboration, since it is well-known that to nowadays tubulin-targeted medicines, such as taxanes or vinca-alkaloids, resistance develops rather quickly, so it consists a large problem in oncology. This work reveals basic microtubule functions, violations that it may undergo and consequences of these. Also it is described here the main modern tendencies in creation of remedy which will make it possible breakthrough treatment resistance barrier.

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