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Tuberculosis-HIV Co-Infection: Progress and Challenges After Two Decades of Global Antiretroviral Treatment Roll-Out.

Authors
  • Letang, Emilio1
  • Ellis, Jayne2
  • Naidoo, Kogieleum3
  • Casas, Esther C4
  • Sánchez, Paquita5
  • Hassan-Moosa, Razia3
  • Cresswell, Fiona6
  • Miró, Jose M7
  • García-Basteiro, Alberto L8
  • 1 ISGlobal, Hospital Clínic-Universitat de Barcelona, Barcelona, Spain; Infectious Diseases Department, Hospital del Mar, Hospital del Mar Research Institute, Barcelona, Spain. Electronic address: [email protected] , (Spain)
  • 2 Infectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda; Hospital for Tropical Diseases, University College London, London, UK. , (Uganda)
  • 3 Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa; MRC-CAPRISA HIV-TB Pathogenesis and Treatment Research Unit, Doris Duke Medical Research Institute, University of KwaZulu-Natal, South Africa. , (South Africa)
  • 4 Southern Africa Medical Unit, Médecins sans Frontières, Cape Town, South Africa. , (South Africa)
  • 5 Infectious Diseases Department, Hospital del Mar, Hospital del Mar Research Institute, Barcelona, Spain. , (Spain)
  • 6 Infectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda; Clinical Research Department, London School of Hygiene and Tropical Medicine, London, UK; MRC-UVRI-London School of Hygiene and Tropical Medicine Uganda Research Unit, Entebbe, Uganda. , (Uganda)
  • 7 Infectious Diseases Service, Hospital Clínic-IDIBAPS, University of Barcelona, Barcelona, Spain. , (Spain)
  • 8 ISGlobal, Hospital Clínic-Universitat de Barcelona, Barcelona, Spain; Centro de Investigação em Saúde de Manhiça (CISM), Maputo, Mozambique. , (Spain)
Type
Published Article
Journal
Archivos de bronconeumologia
Publication Date
Jul 01, 2020
Volume
56
Issue
7
Pages
446–454
Identifiers
DOI: 10.1016/j.arbres.2019.11.015
PMID: 31932150
Source
Medline
Keywords
Language
Spanish
License
Unknown

Abstract

Despite wide antiretroviral scale-up during the past two decades resulting in declining new infections and mortality globally, HIV-associated tuberculosis remains as a major public health concern. Tuberculosis is the leading HIV-associated opportunistic infection and the main cause of death globally and, particularly, in resource-limited settings. Several challenges exist regarding diagnosis, global implementation of latent tuberculosis treatment, management of active tuberculosis, delivery of optimal patient-centered TB and HIV prevention and care in high burden countries. In this article we review the advances on pathogenesis, diagnosis, and treatment after nearly two decades of global roll-out of antiretroviral therapy and discuss the current challenges for the global control of tuberculosis-HIV co-infection. Copyright © 2020. Publicado por Elsevier España, S.L.U.

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