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Tuberculosis vaccine development; from mouse to man.

Authors
  • Reed, Steven
  • Lobet, Yves
Type
Published Article
Journal
Microbes and Infection
Publisher
Elsevier
Publication Date
May 01, 2005
Volume
7
Issue
5-6
Pages
922–931
Identifiers
PMID: 15935717
Source
Medline
License
Unknown

Abstract

A tuberculosis (TB) vaccine candidate, Mtb72, was developed following an antigen discovery program involving a combination of expression cloning strategies and evaluation of human immune responses. Adjuvant selection was also performed, resulting in the prioritization of AS02A and AS01B, and an industrial process for vaccine production was developed. Safety, immunogenicity, and protection studies in mice, guinea pigs, rabbits, and monkeys supported the initiation of clinical development of Mtb72f in AS02A.

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