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T-type calcium channels regulate the acquisition and recall of conditioned fear in male, Wistar rats.

Authors
  • Marks, Wendie N1
  • Zabder, Nadine K2
  • Snutch, Terrance P3
  • Howland, John G2
  • 1 Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, AB, T2N 4N1, Canada. Electronic address: [email protected] , (Canada)
  • 2 Department of Anatomy, Physiology, and Pharmacology, University of Saskatchewan, Saskatoon, SK, S7N 5E5, Canada. , (Canada)
  • 3 Michael Smith Laboratories and Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada. , (Canada)
Type
Published Article
Journal
Behavioural brain research
Publication Date
Jun 03, 2020
Volume
393
Pages
112747–112747
Identifiers
DOI: 10.1016/j.bbr.2020.112747
PMID: 32504730
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The T-type calcium channel blocker, Z944, has been used as a pharmacological tool to assess T-type calcium channel function and examined for use as an anti-epileptic. As Z944 affects fear learning and memory in a rodent model of absence epilepsy, it is important to determine the effect of Z944 on learning and memory in a non-disease outbred rodent strain. This study examined the dose-dependent effects (5 mg/kg, 10 mg/kg, i.p.) of acute systemic treatment with Z944 on the learning and memory of fear conditioning and extinction in male Wistar rats. Z944 administered prior to the acquisition of fear conditioning significantly increased freezing prior to acquisition and extinction, during acquisition, and impaired recall of fear memory 24 h later. These findings suggest that T-type calcium channel activity may be required during associative learning for intact long-term memory. Enhanced fear behaviour observed prior to acquisition and extinction, and during acquisition could reflect an increase in anxiety, however, further testing is needed to determine the effect of Z944 on anxiety during fear conditioning and extinction. The use of Z944 for therapeutic purposes should consider the potential effects of Z944 on learning and memory in clinical populations. Copyright © 2020 Elsevier B.V. All rights reserved.

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