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Tsetse-trypanosome interactions: rites of passage.

Authors
Type
Published Article
Journal
Parasitology Today
0169-4758
Publisher
Elsevier
Publication Date
Volume
15
Issue
10
Pages
399–403
Identifiers
PMID: 10481151
Source
Medline

Abstract

Trypanosomes that cause sleeping sickness (Trypanosoma brucei rhodesiense and T. b. gambiense) are entirely dependent on tsetse for their transmission between hosts, but the flies are not easily infected. This situation has not arisen by chance - the tsetse has evolved an efficient defence system against trypanosome invasion. In this review, Susan Welburn and Ian Maudlin chart the progress of trypanosomes through the fly and identify some of the hazards faced by both parasite and fly that affect vector competence of tsetse.

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