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TRPM8 activation improves energy expenditure in skeletal muscle and exercise endurance in mice.

Authors
  • Li, Chen1
  • Li, Jia2
  • Xiong, Xiujuan3
  • Liu, Ying4
  • Lv, Yanxia3
  • Qin, Shanshan4
  • Liu, Dandan3
  • Wei, Ronghua3
  • Ruan, Xuzhi3
  • Zhang, Jingxuan3
  • Xu, Liang5
  • Wang, Xuanbin5
  • Chen, Jicheng6
  • Zhang, Yonghong7
  • Zheng, Lanlan8
  • 1 Laboratory of Chinese Herbal Pharmacology, Oncology Center, Renmin Hospital, Hubei University of Medicine, Shiyan 442000, China; Laboratory of Medicinal Plant, School of Basic Medicine, Hubei University of Medicine, Shiyan 442000, China. , (China)
  • 2 School of Medicine, Jinhua Polytechnic, Jinhua, Zhejiang, China. , (China)
  • 3 Laboratory of Medicinal Plant, School of Basic Medicine, Hubei University of Medicine, Shiyan 442000, China. , (China)
  • 4 Laboratory of Molecular Target Therapy of Cancer, Institute of Basic Medical Sciences, Hubei University of Medicine, Shiyan, Hubei 442000, China. , (China)
  • 5 Laboratory of Chinese Herbal Pharmacology, Oncology Center, Renmin Hospital, Hubei University of Medicine, Shiyan 442000, China. , (China)
  • 6 Department of Physical Education, Hainan Medical University, Haikou, Hainan 571100, China. Electronic address: [email protected] , (China)
  • 7 Laboratory of Medicinal Plant, School of Basic Medicine, Hubei University of Medicine, Shiyan 442000, China. Electronic address: [email protected] , (China)
  • 8 Laboratory of Medicinal Plant, School of Basic Medicine, Hubei University of Medicine, Shiyan 442000, China. Electronic address: [email protected] , (China)
Type
Published Article
Journal
Gene
Publication Date
Jan 30, 2018
Volume
641
Pages
111–116
Identifiers
DOI: 10.1016/j.gene.2017.10.045
PMID: 29054764
Source
Medline
Keywords
License
Unknown

Abstract

Skeletal muscle serving as the major organ is responsible for energy expenditure and exercise endurance, which directly influence cardiometabolic risk factors. Transient receptor potential melastatin 8 (TRPM8), a Ca2+-permeable non-selective cation channel, plays vital roles in the regulation of various cellular functions. It has been reported that TRPM8 activation enhanced the energy metabolism of adipocytes. However, the involvement of TRPM8 in the energy metabolism of skeletal muscle remains unexplored. Our data revealed that TRPM8 was expressed in cultured C2C12 myocytes. Menthol treatment increased uncoupling protein 1 (UCP1) and peroxisome proliferator-activated receptor-γ coactivator 1α (PGC1α) expression in C2C12 myotubes through TRPM8 activation. Moreover, dietary menthol upregulated the expression of UCP1 and PGC1α in skeletal muscle of mice. In addition, dietary menthol enhanced exercise endurance and reduced blood lactic acid and triglycerides through TRPM8 activation. It is concluded that dietary menthol improves energy metabolism and exercise endurance by increasing UCP1 and PGC1α in skeletal muscles, suggesting dietary menthol might be a novel therapeutic approach for cardiometabolic diseases management and prevention.

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