Trophic action of sympathetic nerves reduces arterial smooth muscle Ca(2+) sensitivity during early post-natal development in rats.
Faculty of Biology, M.V. Lomonosov Moscow State University, Moscow, Russia; Centre for Biomedicine and Medical Technology Mannheim (CBTM), Research Division Cardiovascular Physiology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
- Published Article
Acta physiologica (Oxford, England)
- Publication Date
Oct 01, 2014
Sympathetic denervation reverses developmental changes both in Ca(2+) sensitivity and in the expression of regulatory proteins back to the early post-natal phenotype in the rat saphenous artery. We conclude that trophic effects of sympathetic nerves govern functional remodelling of arteries during early post-natal development.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/24947441