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Trophic action of sympathetic nerves reduces arterial smooth muscle Ca(2+) sensitivity during early post-natal development in rats.

Authors
  • Puzdrova, V A1
  • Kudryashova, T V
  • Gaynullina, D K
  • Mochalov, S V
  • Aalkjaer, C
  • Nilsson, H
  • Vorotnikov, A V
  • Schubert, R
  • Tarasova, O S
  • 1 Faculty of Biology, M.V. Lomonosov Moscow State University, Moscow, Russia; Centre for Biomedicine and Medical Technology Mannheim (CBTM), Research Division Cardiovascular Physiology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. , (Germany)
Type
Published Article
Journal
Acta physiologica (Oxford, England)
Publication Date
Oct 01, 2014
Volume
212
Issue
2
Pages
128–141
Identifiers
DOI: 10.1111/apha.12331
PMID: 24947441
Source
Medline
Keywords
License
Unknown

Abstract

Sympathetic denervation reverses developmental changes both in Ca(2+) sensitivity and in the expression of regulatory proteins back to the early post-natal phenotype in the rat saphenous artery. We conclude that trophic effects of sympathetic nerves govern functional remodelling of arteries during early post-natal development.

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