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Trolox protects mitochondrial complex IV from nitric oxide-mediated damage in astrocytes.

Authors
  • Heales, S J
  • Bolaños, J P
  • Land, J M
  • Clark, J B
Type
Published Article
Journal
Brain Research
Publisher
Elsevier
Publication Date
Dec 30, 1994
Volume
668
Issue
1-2
Pages
243–245
Identifiers
PMID: 7535655
Source
Medline
License
Unknown

Abstract

The efficacy of cystine, ascorbate and trolox, a vitamin E analogue, at protecting against nitric oxide-mediated mitochondrial complex IV damage has been investigated in cultured astrocytes. Of these compounds, only trolox afforded protection. It is suggested that lipid peroxidation is responsible for nitric oxide-mediated mitochondrial damage and that inhibitors of this process may be of therapeutic benefit in conditions where excessive nitric oxide production is implicated.

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