The progression to irreversible liver injury probably occurred within a 1-month interval in most patients, casting doubt on the value of monthly monitoring of serum aminotransferase levels as a means of preventing troglitazone-induced acute liver failure. The cumulative risk of hepatic failure increased with continued use.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/12681458