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tRNAscan-SE On-line: integrating search and context for analysis of transfer RNA genes.

Authors
Type
Published Article
Journal
Nucleic Acids Research
Publisher
Oxford University Press
Volume
44
Issue
W1
Pages
54–57
Identifiers
DOI: 10.1093/nar/gkw413
Source
UCSC Bioinformatics biomedical-ucsc
License
Unknown

Abstract

High-throughput genome sequencing continues to grow the need for rapid, accurate genome annotation and tRNA genes constitute the largest family of essential, ever-present non-coding RNA genes. Newly developed tRNAscan-SE 2.0 has advanced the state-of-the-art methodology in tRNA gene detection and functional prediction, captured by rich new content of the companion Genomic tRNA Database. Previously, web-server tRNA detection was isolated from knowledge of existing tRNAs and their annotation. In this update of the tRNAscan-SE On-line resource, we tie together improvements in tRNA classification with greatly enhanced biological context via dynamically generated links between web server search results, the most relevant genes in the GtRNAdb and interactive, rich genome context provided by UCSC genome browsers. The tRNAscan-SE On-line web server can be accessed at http://trna.ucsc.edu/tRNAscan-SE/.

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