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Triterpenoid saponins with anti-inflammatory activity from Codonopsis lanceolata.

Authors
  • Xu, Li-Ping
  • Wang, Hao
  • Yuan, Zhong
Type
Published Article
Journal
Planta medica
Publication Date
Sep 01, 2008
Volume
74
Issue
11
Pages
1412–1415
Identifiers
DOI: 10.1055/s-2008-1081318
PMID: 18666043
Source
Medline
License
Unknown

Abstract

Six triterpenoid saponins, including a new compound named codonolaside III, were isolated from the roots of Codonopsis lanceolata. The spectral and chemical data revealed the structure of codonolaside III to be 3- O-[ beta- D-xylopyranosyl -(1-->3)- beta- D-glucuronopyranosyl]-3 beta,16 alpha-dihydroxyolean-12-ene-28-oic acid 28- O-[ beta- D-xylopyranosyl-(1-->4)- alpha- L-rhamnpyranosyl-(1-->2)][ beta- D-glucopyranosyl -(1-->4)]- alpha- L-arabinopyranosyl ester. The xylene-induced mouse ear edema inhibitory effect assay disclosed codonolaside and codonolasides I - III as the major anti-inflammatory constituents in this crude drug.

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