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Trisomy 21 and isodicentric chromosome 21 in Kostmann syndrome following treatment with G-CSF.

Authors
  • Roland, B
  • Woodman, R C
  • Jorgenson, K
  • Pinto, A
Type
Published Article
Journal
Cancer Genetics and Cytogenetics
Publisher
Elsevier
Publication Date
Apr 01, 2001
Volume
126
Issue
1
Pages
78–80
Identifiers
PMID: 11343785
Source
Medline
License
Unknown

Abstract

A child with Kostmann syndrome, or severe congenital neutropenia, developed myelodysplastic syndrome after 6 years of treatment with rhG-CSF. The bone marrow karyotype showed acquired trisomy 21, and in some cells pentasomy 21 due to two isodicentric chromosomes 21. This is the second report of a patient with Kostmann syndrome and acquired trisomy 21.

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