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Triplet repeat disorders: discussion of molecular mechanisms.

Authors
Type
Published Article
Journal
Cellular and Molecular Life Sciences
1420-682X
Publisher
Springer-Verlag
Publication Date
Volume
55
Issue
11
Pages
1432–1447
Identifiers
PMID: 10518991
Source
Medline

Abstract

Comparison of the growing number of disorders known to be associated with triplet repeat expansions reveals both common features and a diversity of molecular pathways. Despite significant progress towards the characterization of proteins coded by the mutant genes, the complex nature of these disorders requires identification of all molecular components of the triplet repeat pathways. In this brief review we will discuss recent progress in determining the molecular mechanisms of disorders with unstable trinucleotide mutations.

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