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Trimethoprim-sulfamethoxazole in the treatment of otitis media caused by ampicillin-resistant strains of Haemophilus influenzae.

Authors
  • Schwartz, R H
  • Rodriguez, W J
  • Khan, W N
  • Mann, R
  • Barsanti, R G
  • Ross, S
Type
Published Article
Journal
Reviews of infectious diseases
Publication Date
Jan 01, 1982
Volume
4
Issue
2
Pages
514–516
Identifiers
PMID: 6981169
Source
Medline
License
Unknown

Abstract

Trimethoprim-sulfamethoxazole (TMP-SMZ) was successful treatment for 93% of cases of acute otitis media caused by ampicillin-resistant Haemophilus influenzae studied. All 15 children in this study had symptoms of otitis media that were unrelieved by a course of ampicillin therapy, but 14 of them responded promptly to a 10-day course of TMP-SMZ. Potentially invasive type b strains of H. influenzae were isolated in cultures of the middle ear exudate of three children, all of whom responded well to TMP-SMZ therapy. The middle ear isolates of H. influenzae were sensitive in vitro to TMP-SMZ. It is concluded that TMP-SMZ is effective and convenient for the treatment of otitis media caused by ampicillin-resistant H. influenzae.

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