Current status and prospects for development of a vaccine against Trichomonas vaginalis infections.
University of Ottawa, Faculty of Medicine, Ottawa, ON, Canada.
University of Ottawa, Faculty of Medicine, Ottawa, ON, Canada; Ottawa Hospital Research Institute, Division of Infectious Disease and Public Health Ontario, Ottawa, ON, Canada. Electronic address: [email protected]
- Published Article
- Publication Date
Mar 20, 2014
Trichomonas vaginalis is a sexually transmitted pathogen with an annual worldwide incidence of over 276 million infections, the highest of all curable and non-viral STI. A large proportion of cases are asymptomatic and under-diagnosed with conventional diagnostic tools. Infection has important maternal and fetal health consequences and can lead to a higher probability of HIV transmission and susceptibility. Lack of affordable accurate diagnostic tests globally and metronidazole resistance hinder T. vaginalis control efforts. Based on data from current vaccination studies in animal models, a human vaccine is achievable to intervene on the substantial incidence of infection.
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This record was last updated on 06/09/2018 and may not reflect the most current and accurate biomedical/scientific data available from NLM.
The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/23916988