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A Triad of Crystals Sheds Light on MDGA Interference with Neuroligation

Authors
  • Thoumine, Olivier
  • Marchot, Pascale
Publication Date
Aug 01, 2017
Source
Kaleidoscope Open Archive
Keywords
Language
English
License
Unknown
External links

Abstract

Neurexins and neuroligins form trans-synaptic complexes that promote synapse development. In this issue of Neuron, Aricescu and colleagues (Elegheert et al., 2017) complement and strengthen two recent reports by the Kim and Rudenko teams (Kim et al., 2017; Gangwar et al., 2017) to dissect the molecular determinants by which MDGAs challenge the neurexin-neuroligin partnership.

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