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Trefoil Factor Family 1 Is Involved in Airway Remodeling of Mustard Lung.

Authors
  • Nourani, Mohammad Reza1
  • Farajpour, Zahra1
  • Najafi, Ali2
  • Imani Fooladi, Abbas Ali3
  • 1 Genomic Division, Systems Biology Institute, Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. , (Iran)
  • 2 Molecular Biology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. , (Iran)
  • 3 Applied Microbiology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. , (Iran)
Type
Published Article
Journal
Iranian journal of allergy, asthma, and immunology
Publication Date
Aug 01, 2016
Volume
15
Issue
4
Pages
275–282
Identifiers
PMID: 27921407
Source
Medline
Keywords
License
Unknown

Abstract

Human airway is generally destructed by inhaled factors and is the barrier to the external environment and has a crucial role in protection of the internal homeostasis of the lung. Sulfur mustard (SM) is a chemical warfare that capable of producing severe chemical injuries primarily in the lungs. Trefoil factor family (TFFs) plays major roles in epithelial repair and homeostasis, particularly in the lung. This study attempted to verify the role of TFFs in airway that induced by sulfur mustard. Fifteen patients exposed to SM and 10 non-exposed subjects were enrolled in this study. Bronchoscopy was carried out and endobronchial biopsy specimens were taken. The TFFs gene expressions were evaluated by RT-PCR. The results revealed that the TFF1 was overexpressed in exposed subjects in comparison to non-exposed subjects. In conclusion, TFF1 displays a distinct protein expression pattern in the developing of airway remodeling due to SM inhalation and plays an important role in maintaining the airway epithelium function.

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