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Treatment strategies for Zollinger-Ellison syndrome.

Authors
  • Wilcox, C Mel
  • Hirschowitz, Basil I
Type
Published Article
Journal
Expert Opinion on Pharmacotherapy
Publisher
Informa UK (Taylor & Francis)
Publication Date
May 01, 2009
Volume
10
Issue
7
Pages
1145–1157
Identifiers
DOI: 10.1517/14656560902887035
PMID: 19351273
Source
Medline
License
Unknown

Abstract

The clinical manifestations of ZES are well described, but overlaps with other more common disorders delay diagnosis. The use of abdominal imaging with somatostatin receptor scintigraphy and endoscopic ultrasound has improved tumor staging. PPI therapy is remarkably effective in controlling gastric acid hypersecretion, thereby reducing morbidity and potential mortality of this syndrome. The dose of drug necessary to control symptoms is highly variable but, even when used in high doses for prolonged periods of time, the disease remained controlled with very few drug-related side effects.

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