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Treatment of peanut allergy and colitis in mice via the intestinal release of butyrate from polymeric micelles

Authors
  • Wang, Ruyi
  • Cao, Shijie
  • Bashir, Mohamed Elfatih H
  • Hesser, Lauren A
  • Su, Yanlin
  • Hong, Sung Min Choi
  • Thompson, Andrew
  • Culleen, Elliot
  • Sabados, Matthew
  • Dylla, Nicholas P
  • Campbell, Evelyn
  • Bao, Riyue
  • Nonnecke, Eric B
  • Bevins, Charles L
  • Wilson, D Scott
  • Hubbell, Jeffrey A
  • Nagler, Cathryn R
Publication Date
Jan 01, 2023
Source
eScholarship - University of California
Keywords
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Abstract

The microbiome modulates host immunity and aids the maintenance of tolerance in the gut, where microbial and food-derived antigens are abundant. Yet modern dietary factors and the excessive use of antibiotics have contributed to the rising incidence of food allergies, inflammatory bowel disease and other non-communicable chronic diseases associated with the depletion of beneficial taxa, including butyrate-producing Clostridia. Here we show that intragastrically delivered neutral and negatively charged polymeric micelles releasing butyrate in different regions of the intestinal tract restore barrier-protective responses in mouse models of colitis and of peanut allergy. Treatment with the butyrate-releasing micelles increased the abundance of butyrate-producing taxa in Clostridium cluster XIVa, protected mice from an anaphylactic reaction to a peanut challenge and reduced disease severity in a T-cell-transfer model of colitis. By restoring microbial and mucosal homoeostasis, butyrate-releasing micelles may function as an antigen-agnostic approach for the treatment of allergic and inflammatory diseases.

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