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Treatment of lobar atelectasis with bronchoscopically administered recombinant human deoxyribonuclease in cystic fibrosis?

Authors
  • McLaughlin, Anne Marie
  • McGrath, Emmet
  • Barry, Rupert
  • Egan, Jim J
  • Gallagher, Charles G
Type
Published Article
Journal
The Clinical Respiratory Journal
Publisher
Wiley (Blackwell Publishing)
Publication Date
Apr 01, 2008
Volume
2
Issue
2
Pages
123–126
Identifiers
DOI: 10.1111/j.1752-699X.2007.00024.x
PMID: 20298317
Source
Medline
License
Unknown

Abstract

We found this method successful in treating lobar atelectasis, which was resistant to conventional therapy with antibiotics and physiotherapy. In all but one of the cases we described, administration of DNase in this manner resulted in a radiographic and clinical improvement of the atelectasis. We recommend that respiratory physicians consider this as a second line treatment in the management of atelectasis.

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