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Treatment of latent syphilis in HIV-infected patients with 10 d of benzylpenicillin G benethamine: a prospective study in Maputo, Mozambique.

Authors
  • Tattevin, Pierre
  • Renault, Patrick
  • Joly, Véronique
  • Bastos, Rui
  • Coelho, Elisabeth
  • Adda, Christian
  • Ebel, Anne
  • Yeni, Patrick
Type
Published Article
Journal
Scandinavian journal of infectious diseases
Publication Date
Jan 01, 2002
Volume
34
Issue
4
Pages
257–261
Identifiers
PMID: 12064687
Source
Medline
License
Unknown

Abstract

Neurosyphilis has been reported in HIV-infected patients previously treated with penicillin G benzathine, which does not achieve treponemicidal levels in cerebrospinal fluid. Therapy combining benzylpenicillin G and its repository form benzylpenicillin G benethamine could be a potentially effective alternative enhanced regimen for treating latent syphilis in HIV-infected patients because peak serum and cerebrospinal fluid concentrations would be achieved early post-administration by the former molecule and sustained for 24 h due to the prolonged half-life of the latter. In this study, 23 asymptomatic HIV and Treponema pallidum co-infected patients received 10 d of combined therapy (2 M IU intramuscular once daily) and were followed up at 3, 6 and 12 months. None experienced side effects or clinical symptoms. Of the 18 patients who were evaluated 1 y later, 8 (44.4%) exhibited serological treatment failure, defined as a positive serum rapid plasma reagin test. In conclusion, a 10-d regimen combining penicillin G and penicillin G benethamine seems to be of no benefit compared to currently recommended treatment.

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