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Treatment of enterococcal pyelonephritis with trovafloxacin and rifampin: in vitro-in vivo contrast.

Authors
  • Montgomerie, J Z
  • Schick, D G
Type
Published Article
Journal
Antimicrobial agents and chemotherapy
Publication Date
Jan 01, 1998
Volume
42
Issue
1
Pages
188–189
Identifiers
PMID: 9449285
Source
Medline
License
Unknown

Abstract

The in vitro bactericidal interaction of trovafloxacin and rifampin against Enterococcus spp. has indicated that antagonism occurs between these two antimicrobial agents. This drug combination was examined in vivo in rats with experimental pyelonephritis. The rats received trovafloxacin, rifampin, or both drugs. On the basis of the mean log10 CFU of Enterococcus faecalis from the kidneys, there was no evidence that trovafloxacin and rifampin were antagonistic in vivo.

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