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Treatment of early seropositive rheumatoid arthritis: doxycycline plus methotrexate versus methotrexate alone.

Authors
Type
Published Article
Journal
Arthritis and rheumatism
Publication Date
Volume
54
Issue
2
Pages
621–627
Identifiers
PMID: 16447240
Source
Medline

Abstract

In patients with early seropositive RA, initial therapy with MTX plus doxycycline was superior (based on an ACR50 response) to treatment with MTX alone. The therapeutic responses to low-dose and high-dose doxycycline were similar, suggesting that the antimetalloproteinase effects were more important than the antibacterial effects. Further studies to evaluate the mechanism of action of tetracyclines in RA are indicated.

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