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Treatment of depressive-like behaviour in Huntington's disease mice by chronic sertraline and exercise.

Authors
  • Renoir, Thibault
  • Pang, Terence Y C
  • Zajac, Michelle S
  • Chan, Grace
  • Du, Xin
  • Leang, Leah
  • Chevarin, Caroline
  • Lanfumey, Laurence
  • Hannan, Anthony J
Type
Published Article
Journal
British Journal of Pharmacology
Publisher
Wiley (Blackwell Publishing)
Publication Date
Mar 01, 2012
Volume
165
Issue
5
Pages
1375–1389
Identifiers
DOI: 10.1111/j.1476-5381.2011.01567.x
PMID: 21718306
Source
Medline
License
Unknown

Abstract

We report for the first time a crucial role for 5-HT(1A) autoreceptor function in mediating the sex-specific depressive-like phenotype of female R6/1 HD mice. Our data further support a differential effect of chronic sertraline treatment and exercise on hippocampal cell proliferation despite common behavioural benefits.

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