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Treatment of coumarin-associated coagulopathy: a systematic review and proposed treatment algorithms.

Authors
  • Dentali, F
  • Ageno, W
  • Crowther, M
Type
Published Article
Journal
Journal of thrombosis and haemostasis : JTH
Publication Date
Sep 01, 2006
Volume
4
Issue
9
Pages
1853–1863
Identifiers
PMID: 16961594
Source
Medline
License
Unknown

Abstract

Vitamin K therapy is an effective treatment for INR prolongation in patients with coumarin-associated coagulopathy; coagulation factor replacement is required, in addition, in patients with major bleeding or with indication for immediate correction of their INR. Clinical trials powered to detect differences in rates of bleeding and thrombosis are now required to determine if vitamin K reduces the risk of bleeding without causing thrombosis in non-bleeding patients with prolonged INR.

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