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Treatment of American cutaneous leishmaniasis: a comparison between low dosage (5 mg/kg/day) and high dosage (20 mg/kg/day) antimony regimens.

Authors
  • Oliveira-Neto, M P
  • Schubach, A
  • Mattos, M
  • Gonçalves-Costa, S C
  • Pirmez, C
Type
Published Article
Journal
Pathologie Biologie
Publisher
Elsevier
Publication Date
Jun 01, 1997
Volume
45
Issue
6
Pages
496–499
Identifiers
PMID: 9309267
Source
Medline
License
Unknown

Abstract

Twenty-three patients from Rio de Janeiro, Brazil-an area of Leishmania (Viannia) braziliensis transmission-were randomly assigned to receive either a high dose (20 mg/kg/day) of antimony or a lower one (5 mg/kg/day) in a 30 days series. The two treatment regimens showed similar responses. In 10 out of 12 patients receiving a dose of 5 mg/kg/day and 9 out of 11 patients with a dosage of 20 mg/kg/day a complete epithelization was noted by the end of treatment. In addition patients were followed for up to 7 years. No reactivation or development of mucosal lesions were observed in both groups during the extensive follow-up. We think that a low dosage of antimony could be equally effective than a higher one, at least in the presence of the clinical picture usually seen in Rio de Janeiro.

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