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Treadmill training in patients affected by Charcot-Marie-Tooth neuropathy: results of a multicenter, prospective, randomized, single-blind, controlled study.

  • Mori, L1, 2
  • Signori, A3
  • Prada, V1
  • Pareyson, D4
  • Piscosquito, G5
  • Padua, L6
  • Pazzaglia, C7
  • Fabrizi, G M8
  • Picelli, A9
  • Schenone, A1, 2
  • 1 Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genoa, Italy. , (Italy)
  • 2 IRCCS Ospedale Policlinico San Martino, Genoa, Italy. , (Italy)
  • 3 Department of Health Science, Biostatistics Section, University of Genoa, Genoa, Italy. , (Italy)
  • 4 Fondazione IRCCS, Istituto Neurologico Carlo Besta, Milan, Italy. , (Italy)
  • 5 Functional Neuromotor Rehabilitation Unit, IRCCS 'ICS Maugeri Spa - SB' Scientific Institute of Telese Terme, Telese Terme, Italy. , (Italy)
  • 6 Department of Geriatrics, Neurosciences and Orthopedics, Catholic University of Sacred Heart, Rome, Italy. , (Italy)
  • 7 Fondazione Don Carlo Gnocchi Onlus, Milan, Italy. , (Italy)
  • 8 Neurology Section, Department of Neuroscience, Biomedicine and Movement Sciences, University of Verona, Verona, Italy. , (Italy)
  • 9 Neuromotor and Cognitive Rehabilitation Research Center, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy. , (Italy)
Published Article
European journal of neurology
Publication Date
Aug 24, 2019
DOI: 10.1111/ene.14074
PMID: 31444929


Muscle-strengthening, stretching or proprioceptive treatments may slow symptom progression in Charcot-Marie-Tooth (CMT) neuropathy. The aim of the study was to evaluate safety and efficacy of treadmill training in CMT1A. We planned a multicenter, prospective, randomized, single-blind, controlled study. We recruited 53 outpatients affected by CMT1A and randomized them into two treatment groups: one underwent stretching and proprioceptive exercise, whereas the other was additionally treated with treadmill training (TreSPE). Primary outcome measures (OMs) were the walking evaluations and secondary OM was the balance assessment. All participants were assessed at baseline and after 3 and 6 months of treatment. Most patients showed an improvement in at least one OM after 3 months [42/47 (89.4%)] and 6 months [38/40 (95%)] of treatment. No adverse events were reported in either group. The most important finding was that both stretching and proprioceptive exercise and treadmill training had an objective benefit on patients affected by CMT disease, without causing overwork weakness. We had a low rate of drop out and did not find deterioration in motor performance. Our results also confirm that applying evidence-based medicine methods to rehabilitative research is the correct way to test the efficacy of a treatment. © 2019 The Authors. European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology.

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