Affordable Access

deepdyve-link
Publisher Website

Transport of lipopolysaccharide across the cell envelope: the long road of discovery.

Authors
  • Ruiz, Natividad
  • Kahne, Daniel
  • Silhavy, Thomas J
Type
Published Article
Journal
Nature Reviews Microbiology
Publisher
Springer Nature
Publication Date
Sep 01, 2009
Volume
7
Issue
9
Pages
677–683
Identifiers
DOI: 10.1038/nrmicro2184
PMID: 19633680
Source
Medline
License
Unknown

Abstract

Intracellular lipid transport is poorly understood. Genetic studies to identify lipid-transport factors are complicated by the essentiality of many lipids, whereas biochemical and cell biology approaches aiming to determine localization and mechanisms of lipid transport are often challenged by the lack of adequate technology. Here, we review the epic history of how different approaches, technological advances and ingenuity contributed to the recent discovery of a multi-protein pathway that transports lipopolysaccharide across the envelope of Gram-negative bacteria.

Report this publication

Statistics

Seen <100 times