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Transport of intranasally instilled fine Fe2O3 particles into the brain: Micro-distribution, chemical states, and histopathological observation

  • Wang, B
  • Feng, WY
  • Wang, M
  • Shi, JW
  • Zhang, F
  • Ouyang, H
  • Zhao, YL
  • Huang, YY
  • Xie, YN
  • Wang, HF
  • Wang, J
Publication Date
Jan 01, 2007
UTS Institutional Repository
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It has been demonstrated that inhaled fine (d<2.5 µm) and ultrafine (d<100 nm) particles produce more severe toxicity than coarse particles. Some recent data support the concept that the central nervous system (CNS) may be a target for the inhaled fine particulates. This work describes initial observation of the transport of intranasally instilled fine ferric oxide (Fe2O3 ) particles in animal brain. The iron micro-distribution and chemical state in the mice olfactory bulb and brain stem on day 14 after intranasal instillation of fine Fe2O3 particle (280±80 nm) suspension at a single dose of 40 mg/kg body weight were analyzed by synchrotron radiation x-ray fluorescence and x-ray absorption near-edge structure (XANES). The micro-distribution map of iron in the olfactory bulb and brain stem shows an obvious increase of Fe contents in the olfactory nerve and the trigeminus of brain stem, suggesting that Fe2O3 particles were possibly transported via uptake by sensory nerve endings of the olfactory nerve and trigeminus.

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